Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain

• New monohydroxylated brassinosteroid analogues were synthesized.
• Biological activities of these derivatives were studied.
• All derivatives were subjected to docking studies using AutoDock Vina.
• The molecular docking showed interesting binding affinity of some compounds prepared to kinase receptor BRI1.

Thirteen monohydroxylated brassinosteroids analogues were synthesized and tested for their biological activity in plant and animal systems. The cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard.

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