کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2027984 | 1070387 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic cardenolides from the stems of Periploca forrestii
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytotoxic cardenolides from the stems of Periploca forrestii Cytotoxic cardenolides from the stems of Periploca forrestii](/preview/png/2027984.png)
چکیده انگلیسی
Six new cardenolides, periforosides D–E (1–2), periforgenin C (3) and periforosides F–H (4–6), as well as 10 previously identified cardenolides (7–16) were isolated from the ethanol extract of the stems of Periploca forrestii. The structures of the new compounds were determined using extensive spectroscopic analyses including HRESI-MS, 1D and 2D NMR data. Evaluation of the cytotoxic activity of all the isolated compounds in five different human cancer cell lines indicated that compounds 2–6, 8, 9 and 12–16 have potent activity.
► Six new and 10 known cardenolides were isolated from Periploca forrestii.
► Twelve of the isolated compounds showed cytotoxic activity.
► Preliminary SAR was summarized.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 77, Issue 5, April 2012, Pages 375–381
Journal: Steroids - Volume 77, Issue 5, April 2012, Pages 375–381
نویسندگان
Yong Li, Yun-Bao Liu, Shi-Shan Yu, Xiao-Guang Chen, Xian-Fu Wu, Shuang-Gang Ma, Jing Qu, You-Cai Hu, Jing Liu, Hai-Ning Lv,