کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028013 1070388 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Synthesis and antifungal activity of C-21 steroids with an aromatic D ring
چکیده انگلیسی

Six analogues of salpichrolides with a simplified side chain (6–11) were synthesized using a new methodology to obtain steroids with an aromatic D-ring. The key step was the elimination of HBr in a vicinal dibromo D-homosteroid by treatment with 1,4-diazabicyclo[2.2.2]octane (DABCO). All new compounds were completely characterized by 2D NMR techniques and tested on two fungal pathogenic species, Fusarium virguliforme and Fusarium solani.


► A simple methodology for the preparation of steroids with an aromatic D ring was developed.
► Six analogues of salpichrolides with an aromatic D ring and a simplified side chain were synthesized.
► The antifungal activity was evaluated on two fungal pathogenic species: Fusarium virguliforme and Fusarium solani.
► Two analogues had activity comparable to the natural salpichrolides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 78, Issue 7, July 2013, Pages 644–650
نویسندگان
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