کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028013 | 1070388 | 2013 | 7 صفحه PDF | دانلود رایگان |

Six analogues of salpichrolides with a simplified side chain (6–11) were synthesized using a new methodology to obtain steroids with an aromatic D-ring. The key step was the elimination of HBr in a vicinal dibromo D-homosteroid by treatment with 1,4-diazabicyclo[2.2.2]octane (DABCO). All new compounds were completely characterized by 2D NMR techniques and tested on two fungal pathogenic species, Fusarium virguliforme and Fusarium solani.
► A simple methodology for the preparation of steroids with an aromatic D ring was developed.
► Six analogues of salpichrolides with an aromatic D ring and a simplified side chain were synthesized.
► The antifungal activity was evaluated on two fungal pathogenic species: Fusarium virguliforme and Fusarium solani.
► Two analogues had activity comparable to the natural salpichrolides.
Journal: Steroids - Volume 78, Issue 7, July 2013, Pages 644–650