کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028237 | 1070403 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone](/preview/png/2028237.png)
A new stereoselective synthesis of E-guggulsterone is described starting from androsten-3,17-dione. Protection of the ring A enonic system, followed by regioselective Wittig reaction and C-16 oxidation, affords E-guggulsterone in good yields and high stereoselectivity, making this approach easily accessible and scalable. Moreover, an original normal-phase HPLC method enabling the fast quantitation of the guggulsterone isomeric purity, combined with the suitability for sampling procedures, is detailed. The relying upon the cellulose-based Chiralpak IB column and the chloroform as the “non-standard” component of the eluent mixture, allows to get profitably high chromatographic performances.
► New stereoselective synthesis of E-guggulsterone.
► Regioselective Wittig reaction and C-16 oxidation.
► The approach is easily accessible and scalable.
► Normal-phase HPLC method for the fast quantitation of the guggulsterone isomeric purity.
Journal: Steroids - Volume 77, Issue 3, February 2012, Pages 250–254