کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028238 1070403 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antiproliferative activity of some steroidal lactone compounds
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Synthesis and antiproliferative activity of some steroidal lactone compounds
چکیده انگلیسی

Using cholesterol as starting material, some steroidal lactone compounds with the structures of 3-substituted-6-oxo-7-oxa-B-homo-cholestane or 3-substituted-7-oxo-6-oxa-B-homo-cholestane were synthesized by oxidation, reduction, Baeyer–Villiger reaction and condensation reaction. The cytotoxicity of these compounds against MGC 7901 (human gastric carcinoma), HeLa (human cervical carcinoma) and SMMC 7404 (human liver carcinoma) cells was investigated. Our results showed that the synthesized compounds displayed a distinct cytotoxicity against these cancer cells. In particular, compounds 8 and 9 have similar cytotoxic capability as cisplatin does. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.


► A new series of B-homo-lactone derivatives of cholestane was synthesized.
► The synthesized compounds displayed a distinct cytotoxicity.
► The cytotoxicity of compounds 8 and 9 is similar to cisplatin’s.
► The 8 remarkably increased its cytotoxicity in comparison with its precursor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 77, Issue 3, February 2012, Pages 255–259
نویسندگان
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