کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028273 1542731 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brassinosteroids and analogs as neuroprotectors: Synthesis and structure–activity relationships
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Brassinosteroids and analogs as neuroprotectors: Synthesis and structure–activity relationships
چکیده انگلیسی

We have demonstrated previously that the brassinosteroid (BR) 24-epibrassinolide exerts neuroprotective effects deriving from its antioxidative properties. In this study, we synthesized 2 natural BRs and 5 synthetic analogs and analyzed their neuroprotective actions in neuronal PC12 cells, against 1-methyl-4-phenylpyridinium (MPP+), a neurotoxin known to induce oxidative stress and degenerescence of dopaminergic neurons characteristic of Parkinsonian brains. We also tested the neuroprotective potential of 2 commercially available BRs. Our results disclosed that 6 of the 9 BRs and analogs tested protected neuronal PC12 cells against MPP+ toxicity. In addition, our structure–activity study suggests that the steroid B-ring and lateral chain play an important role for their neuroprotective action.


► We synthesized 2 natural BRs and 5 synthetic analogs.
► Neuroprotective action in neuronal PC12 cells, against MPP+ was tested.
► Some brassinosteroids exhibit neuroprotection.
► Steroid B-ring and lateral chain functionalities are important for neuroprotection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 77, Issues 1–2, January 2012, Pages 91–99
نویسندگان
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