کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028273 | 1542731 | 2012 | 9 صفحه PDF | دانلود رایگان |

We have demonstrated previously that the brassinosteroid (BR) 24-epibrassinolide exerts neuroprotective effects deriving from its antioxidative properties. In this study, we synthesized 2 natural BRs and 5 synthetic analogs and analyzed their neuroprotective actions in neuronal PC12 cells, against 1-methyl-4-phenylpyridinium (MPP+), a neurotoxin known to induce oxidative stress and degenerescence of dopaminergic neurons characteristic of Parkinsonian brains. We also tested the neuroprotective potential of 2 commercially available BRs. Our results disclosed that 6 of the 9 BRs and analogs tested protected neuronal PC12 cells against MPP+ toxicity. In addition, our structure–activity study suggests that the steroid B-ring and lateral chain play an important role for their neuroprotective action.
► We synthesized 2 natural BRs and 5 synthetic analogs.
► Neuroprotective action in neuronal PC12 cells, against MPP+ was tested.
► Some brassinosteroids exhibit neuroprotection.
► Steroid B-ring and lateral chain functionalities are important for neuroprotection.
Journal: Steroids - Volume 77, Issues 1–2, January 2012, Pages 91–99