The non-genomic rapid acidification in peripheral T cells by progesterone depends on intracellular calcium increase and not on Na+/H+-exchange inhibition

► Three rapid non-genomic responses that involve plasma membrane sites by progesterone. ► Responses in internal calcium elevation, acidification, Na+/H+-exchange 1 inhibition. ► The intracellular calcium increase occurs not via Gi. ► Acidification is dependent on intracellular calcium increase. ► Na+/H+-exchange is not mediated in the response of acidification by progesterone.