Synthesis, characterization and biological evaluation of some 16E-arylidene androstane derivatives as potential anticancer agents

A series of new 16E-arylidene androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activities against the human cancer cell lines SW480, A549, HepG2 and HeLa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC50 values lower than 20 μM against the four cancer cell lines.

. A series of new 16E-arylidene androstane derivatives were synthesized and evaluated for their anticancer activities against four cancer cell lines SW480, A549, HepG2 and HeLa in vitro.Figure optionsDownload as PowerPoint slideHighlights
► 32 new 16E-arylidene androstane derivatives were synthesized and characterized.
► All the compounds evaluated for their anticancer activity against human cancer cell lines of SW480, A549, HepG2 and HeLa.
► Structure–activity relationship study indicated that different substituents at C-16 and C-3 play an important role in determining anticancer activity.