کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2028908 1070452 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective reactivity of 2-mercaptoethanol with 5β,6β-epoxide in steroids from Withania somnifera
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Selective reactivity of 2-mercaptoethanol with 5β,6β-epoxide in steroids from Withania somnifera
چکیده انگلیسی

2-Mercaptoethanol reacts selectively with the 5β,6β-epoxy steroids isolated from Withania somnifera substituting the epoxide by a six-membered oxyethylene-2′-thio ring whereas it failed to show such reactivity on 6α,7α-epoxy withasteroids. The structure of the product has been elucidated by spectroscopic methods, especially applying extensive 2D NMR methods. The anticancer activity of withaferin A was lost in the reaction product indicating that its activity is also linked to the free 5β,6β-epoxide functional group.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 73, Issue 3, March 2008, Pages 245–251
نویسندگان
, , , , , ,