کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2029095 | 1070475 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Antiangiogenesis in swine ovarian follicle: A potential role for 2-methoxyestradiol Antiangiogenesis in swine ovarian follicle: A potential role for 2-methoxyestradiol](/preview/png/2029095.png)
Inhibition of angiogenesis is an important new approach for cancer treatment and the research on this topic deserve special attention. 2-Methoxyestradiol (2-ME), a molecule shown to possess antiangiogenic activity, is a naturally occurring derivative of estradiol which can be potentially produced in the ovarian follicle. This study was therefore aimed firstly to asses 2-ME content in swine follicular fluid. Moreover, we evaluated the effect of this substance on VEGF production, superoxide anion generation (O2−) and superoxide dismuatase activity in granulosa cells. Our data evidence that 2-ME is present in follicular fluid where it potentially acts as a physiological inhibitor of angiogenesis by reducing VEGF production by granulosa cells: this effect could be mediated by a decrease of O2− generation.
Journal: Steroids - Volume 72, Issue 8, July 2007, Pages 660–665