Keywords: 5α-DHT; 5α-dihydrotestosterone; 3α-HSOR; 3α-hydroxysteroid oxidoreductase; 3α-Diol; 3α-androstanediol; WHO; World Health Organisation; CYP; cytochrome; KA; kainic acid; PTZ; pentylenetetrazole; TLE; temporal lobe epilepsy; DG; dentate gyrus; i.p.; i
مقالات ISI (ترجمه نشده)
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Keywords: DHEA; dehydroepiandrosterone; DHEA-S; DHEA-sulfate; 5-Diol; androstenediol; 4-Dione; androstenedione; DHT; dihydrotestosterone; ADT; androsterone; ADT-G; ADT-glucuronide; 3α-diol-3G; androstane-3α, 17β-diol 3-glucuronide; 3α-diol-17G; androstane-3α,
Keywords: MBI; 2-mercaptobenzimidazole; 2-ME; 2-methoxyestradiol; 4-AAP; 4-aminoantipyrine; ATN-224; choline tetrathiomolybdate; CAT; catalase; DDC; N,N'-diethyldithiocarbamate; GPx; glutathione peroxidase; GSH; reduced glutathione; GSSG; oxidized glutathione; MT
Keywords: 17β-Estradiol (E2) (PubChem CID: 5757); Dihydrotestosterone (DHT) (PubChem CID: 10635); 2-Methoxyestradiol (2-ME) (PubChem CID: 66414); Nocodazole (PubChem CID: 4122); Paclitaxel (PubChem CID: 36314); DMF; N,N-dimethylformamide; DMSO; dimethylsulfoxide;
Keywords: Estrogen metabolites; Corpus luteum; 2-Methoxyestradiol; 4-Hydroxyestrone; 16-Ketoestradiol;
Keywords: 2-Methoxyestradiol; 2-methoxyestrone; 16-ketoestradiol; 4-hydroxyestrone; human corpora lutea;
Keywords: Cancer; Hypoxia; Hypoxia-inducible factor (HIF); Neuroblastoma; Pheochromocytoma; Paraganglioma; 2ME2; 2-methoxyestradiol; AmB; amphotericin B; CSC; cancer stem cell; CAIX; carbonic anhydrase IX; ccRCC; clear cell renal cell carcinoma; DCA; dichloroacetic
Keywords: 2-methoxyestradiol; 2-methoxyestradiol-3,17-O,O-bis-sulfamate; crystallization; crystal structure; polymorphism; hydrates/solvates; thermal analysis; dissolution;
Keywords: 2-ME; 2-methoxyestradiol; CAIX; carbonic anhydrase IX; CSC; cancer stem cell; Dtx; docetaxel; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; FIH-1; factor inhibiting HIF-1; GSCs; glioma stem cells; HIF-1; hypoxia-inducible factor-1;
Keywords: Preeclampsia; Lipoxins; Oxidative stress; 2-Methoxyestradiol; Polyunsaturated fatty acids; Vascular endothelial growth factor; Endoglin; Soluble fms-like tyrosine kinase 1;
Keywords: 2ME; 2-methoxyestradiol; HIF; hypoxia-inducible factor; IVC; inferior vena cava; PLGF; placental growth factor; VEGF; vascular endothelial growth factor; Anti-angiogenesis; Hypoxia; Resolution;
Keywords: 2DG; 2-Deoxy-D-glucose; 2-ME; 2-methoxyestradiol; 3NP; 3-nitropropionic acid; ASK1; apoptosis signal-regulating kinase 1; Atg; autophagy-related gene; ATM; ataxia-telangiectasia mutated; Bif-1; Bax-interacting factor-1; BNIP3; Bcl-2/E1B interacting protei
Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol
Keywords: 2-Methoxyestradiol; Cytostatic activity; Anti-angiogenic effects; Tubulin inhibition; Anti-cancer agents; Friedel-Crafts alkylation;
Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling
Keywords: EE; enriched environment; SE; standard environment; SVZ; subventricular zone; Dpi; day(s) post-ischemia; STAT3; signal transducer and activator of transcription 3; NPCs; neural precursor cells; HIF-1α; hypoxia-inducible factor 1α; VEGF; vascular endothe
HIF-1<alpha> Repression of PTEN Transcription Mediates Protective Effects of BMSCs on Neurons During Hypoxia
Keywords: AMPA; 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid; BMSCs; bone marrow mesenchymal stem cells; ChIP-qPCR; Chromatin immunoprecipitation and quantitative Polymerase Chain Reaction; CoCl2; cobalt chloride; Co-IP; co-immunoprecipitation; HIF;
The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro
Keywords: Ac-DEVD-AMC; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin; Ac-DEVD-CHO; N-acetyl-Asp-Glu-Val-Asp-al; Ang2; Angiopoietin-2; AR; androgen receptor; BR; brassinosteroid; CHAPS; 3[(3-cholamidopropyl)dimethylammonio]-propanesulphonic acid; DMEM; Dulbeccoâ
Autophagy in hemorrhagic stroke: Mechanisms and clinical implications
Keywords: AIM2; absent in melanoma 2; AMPK; Adenosine 5â² monophosphate-activated protein kinase; ASC; apoptosis-associated speck-like protein containing a CARD; BBB; blood-brain barrier; BH3; Bcl-2 homology 3; BMVECs; brain microvascular endothelial cells; BNIP3;
Comparison of DSB effects of the beta particles of iodine-131 and 6Â MV X-ray at a dose of 2Â Gy in the presence of 2-Methoxyestradiol, IUdR, and TPT in glioblastoma spheroids
Keywords: DSB damage; Glioblastoma; IUdR; 2-Methoxyestradiol; Topotecan;
Technical noteHigh oral bioavailability of 2-methoxyestradiol in PEG-PLGA micelles-microspheres for cancer therapy
Keywords: 2-Methoxyestradiol; Polymer micelles; pH-sensitive microspheres; Sustained release; Oral bioavailability; Anti-tumor effect;
Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells
Keywords: Melanoma; 2-methoxyestradiol; Estrogen; Chemoresistance;
Design, synthesis and biological evaluation of novel 2-methoxyestradiol analogs as dual selective estrogen receptor modulators (SERMs) and antiangiogenic agents
Keywords: 2-Methoxyestradiol; Estrogen receptor; Antiangiogenesis; Steroids;
Mechanism of antiproliferative action of a new d-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility
Keywords: d-SET; d-secoestrone-triazole; HPV; Human Papilloma Virus; 2-ME; 2-methoxyestradiol; PAC; paclitaxel; Bid; BH3 interacting-domain death agonist; Bcl-2; B-cell CLL/lymphoma 2; FADD; Fas-Associated protein with Death Domain; DISC; death-inducing signalling
Influence of surface passivation of 2-Methoxyestradiol loaded PLGA nanoparticles on cellular interactions, pharmacokinetics and tumour accumulation
Keywords: 2-Methoxyestradiol; PLGA nanoparticles; Drug delivery; Breast cancer; Pharmacokinetics; Tumour accumulation; Protein binding;
The paracrine effect of cobalt chloride on BMSCs during cognitive function rescue in the HIBD rat
Keywords: AMPA; 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid; BMSCs; bone marrow mesenchymal stem cells; CoCl2; cobalt chloride; DMEM; Dulbecco's modified Eagle's medium; DMOG; dimethyloxaloylglycine; DMSO; dimethyl sulfoxide; EPO; erythropoietin
Design, synthesis and antiproliferative effect of 17β-amide derivatives of 2-methoxyestradiol and their studies on pharmacokinetics
Keywords: 2-Methoxyestradiol; Analogs; Antiproliferative effect; Pharmacokinetics;
The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells
Keywords: 2-Methoxyestradiol; 4E-BP; Estrogen metabolite; eIF4E; Osteosarcoma
Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia
Keywords: 2-Methoxyestradiol; preeclampsia; COMT; genotype; MTHFR;
Determination of 2-methoxyestradiol by chemiluminescence based on luminol–KMnO4–CdTe quantum dots system
Keywords: Chemiluminescence; Flow injection; 2-Methoxyestradiol; CdTe quantum-dots
Oxidative modification induced by photodynamic therapy with Photofrin®II and 2-methoxyestradiol in human ovarian clear carcinoma (OvBH-1) and human breast adenocarcinoma (MCF-7) cells
Keywords: Photodynamic reaction; Photofrin®II; 2-Methoxyestradiol; Ovarian carcinoma; Breast adenocarcinoma; Cytoskeleton; Heat shock proteins
2-Methoxyestradiol inhibits bleomycin-induced systemic sclerosis through suppression of fibroblast activation
Keywords: Systemic sclerosis; 2-Methoxyestradiol; Fibrosis; Fibroblast; Collagen
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents
Keywords: CA-4P; combretastatin A-4 phosphate; VEGFR-2; vascular endothelial growth factor receptor-2; RTKs; receptor tyrosine kinases; 2ME2; 2-methoxyestradiol; PDGFR-β; platelet-derived growth factor receptor β; CAM; chorioallantoic membrane; DDQ; 2,3-dichloro-
2-Methoxyestradiol deficiency is strongly related to hypertension in early onset severe pre-eclampsia
Keywords: Pre-eclampsia; 2-Methoxyestradiol; Estradiol; Soluble Fms-like tyrosine kinase-1; Endothelin-1; Nitric oxide
Determination of 2-methoxyestradiol in serum samples and pharmaceutical preparations by silver nanoparticles-enhanced chemiluminescence
Keywords: Silver nanoparticles; Chemiluminescence; 2-methoxyestradiol; Serum samples;
Synthesis, cytotoxic effects and tubulin polymerization inhibition of 1,4-disubstituted 1,2,3-triazole analogs of 2-methoxyestradiol
Keywords: Estrogens; 2-Methoxyestradiol; 1,2,3-Triazoles; Cytotoxicity; Tubulin inhibition; Anti-cancer
Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: Inhibitors of tubulin and angiogenesis
Keywords: 2-Methoxyestradiol; Anti-cancer; Tubulin inhibition; Anti-angiogenesis; Steroids
A novel restricted access material combined to molecularly imprinted polymers for selective solid-phase extraction and high performance liquid chromatography determination of 2-methoxyestradiol in plasma samples
Keywords: Restricted access matrix; Solid phase extraction; Molecular imprinted polymers; 2-Methoxyestradiol; High performance liquid chromatography;
Immunomodulation by the estrogen metabolite 2-methoxyestradiol
Keywords: E2; 17β-Estradiol; 2me2; 2-Methoxyestradiol; COMT; Catechol-O-methyltransferase; ERs; Estrogen receptors; ERE; Estrogen response elements; ovx; Ovariectomized; orx; Orchidectomized; RA; Rheumatoid arthritis; SERM; Selective estrogen receptor modulators;
2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2
Keywords: Sorafenib; 2-Methoxyestradiol; Hepatocellular carcinoma; Hypoxia-inducible factors;
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo
Keywords: AA; arachidonic acid; ALT; alanine aminotransferase; BSO; l-buthionine sulfoximine; CYP2E1; cytochrome P450 2E1; GSH; reduced glutathione; HE; hematoxylin-eosin; 4-HNE; 4-hydroxynonenal; HIF; hypoxia-inducible factor; HPH-2; HIF prolyl hydroxylase 2; IH
2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity
Keywords: 2-methoxyestradiol; human corpus luteum; angiogenic potential; vascular endothelial growth factor;
A simple and convenient synthesis of 2-methoxyestradiol from estrone
Keywords: 2-Methoxyestradiol; Breast cancer; Total synthesis
Synthesis of 3â²-methoxy-E-diethylstilbestrol and its analogs as tumor angiogenesis inhibitors
Keywords: 2-Methoxyestradiol; 3â²-Methoxy-E-diethylstilbestrol; Metabolite; Non-steroidal analog; Angiogenesis inhibitor;
2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells
Keywords: Transforming growth factor β signaling; uterine fibroids; 2-methoxyestradiol;
Taxol alleviates 2-methoxyestradiol-induced endothelial permeability
Keywords: Taxol; 2-methoxyestradiol; Barrier dysfunction; Tubulin acetylation;
Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice
Keywords: 2me2; 2-methoxyestradiol; CL; chemo luminescence; COMT; catechol-O-methyltransferase; conA; concanavilin A; E2; 17β-estradiol; Ig; immunoglobulin; Mcpm; million counts per minute; NK cell; natural killer cell; ROS; reactive oxygen species; TNFα; tumor n
Pharmacologic Effects of 2-Methoxyestradiol on Angiotensin Type 1 Receptor Down-Regulation in Rat Liver Epithelial and Aortic Smooth Muscle Cells
Keywords: Cardiovascular disease; Hypertension; MAPK; 2-Methoxyestradiol
ortho-Formylation of estrogens. Synthesis of the anti-cancer agent 2-methoxyestradiol
Keywords: ortho-Formylation; Estrogens; 2-Methoxyestradiol;
Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy
Keywords: Multifunctional dendrimers; 2-Methoxyestradiol; Encapsulation; Targeted cancer therapy
2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Sensitizes Radioresistant MCF-7/FIR Breast Cancer Cells Through Multiple Mechanisms
Keywords: 2-Methoxyestradiol; γ radiation; Radiosensitizer; Breast cancer;
2-Methoxyestradiol: New perspectives in colon carcinoma treatment
Keywords: Apoptosis; Autophagy; Cell cycle; Colon carcinoma cells; 2-Methoxyestradiol