Dehydroepiandrosterone fatty acyl esters in high density lipoprotein: Interaction with human vascular endothelial cells and vascular responses ex vivo

▶ DHEA ester-enriched HDL induce arterial vasorelaxation via SR-B1-facilitated pathway. ▶ SR-B1 contributes to the uptake of HDL-associated DHEA fatty acyl esters by HUVEC. ▶ Cultured human endothelial cells hydrolyze HDL-associated DHEA fatty acyl esters.