Effect of castration monotherapy on the levels of adrenal androgens in cancerous prostatic tissues

▶ We developed an analytical method for quantifying DHEA, Adione, Adiol, T and DHT simultaneously. ▶ The levels of adrenal androgens in PCa tissues after ADT were similar to those in untreated PCa. ▶ DHEA was the most existing androgen precursor in PCa tissues after ADT.