کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2029463 1542740 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aldosterone-induced signalling and cation transport in the distal nephron
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Aldosterone-induced signalling and cation transport in the distal nephron
چکیده انگلیسی

Aldosterone is an important regulator of Na+ and K+ transport in the distal nephron modulating the surface expression of transporters through the action of the mineralocorticoid receptor as a ligand-dependent transcription factor. Aldosterone stimulates the rapid activation of protein kinase-based signalling cascades that modulate the genomic effects of the hormone. Evidence is accumulating about the multi-factorial regulation of the epithelial sodium channel (ENaC) by aldosterone. Recent published data suggests that the activation of a novel PKC/PKD signalling pathway through the c-Src-dependent trans-activation of epidermal growth factor receptor contributes to early ENaC trafficking in response to aldosterone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 73, Issues 9–10, October 2008, Pages 979–984
نویسندگان
, , ,