کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2035087 1072130 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The 3D Genome as Moderator of Chromosomal Communication
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
The 3D Genome as Moderator of Chromosomal Communication
چکیده انگلیسی

Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 164, Issue 6, 10 March 2016, Pages 1110–1121
نویسندگان
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