کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2041160 1073149 2015 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Experimental Models of Inflammatory Bowel Diseases
ترجمه فارسی عنوان
مدل های تجربی بیماری های روده ای التهابی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی

The understanding of the intestinal inflammation occurring in the inflammatory bowel diseases (IBD) has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD studies has been enabled by our improved knowledge of mucosal immunity and thus our improved ability to interpret the complex responses of mice with various causes of colitis; in addition, it has been powered by the availability of models in which the mice have specific genetic and/or immunologic defects that can be related to the origin of the inflammation. Finally, and more recently, it has been enhanced by our newly acquired ability to define the intestinal microbiome under various conditions and thus to understand how intestinal microorganisms impact on inflammation. In this brief review of murine models of intestinal inflammation, we focus mainly on the most often used models that are, not incidentally, also the models that have yielded major insights into IBD pathogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: CMGH Cellular and Molecular Gastroenterology and Hepatology - Volume 1, Issue 2, March 2015, Pages 154–170
نویسندگان
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