Calcium Signalling: Mitofusins Promote Interorganellar Crosstalk

SummaryJuxtaposition of the endoplasmic reticulum with mitochondria facilitates Ca2+ fluxes between the organelles. However, the molecular basis of interorganellar tethering remains unknown. A recent report has identified a fundamental role for the dynamin-related mitofusins in the tethering mechanism, thereby ensuring rapid and high fidelity Ca2+ signalling between the organelles.