Calcium Signaling: Double Duty for Calcium at the Mitochondrial Uniporter

Uptake of Ca2+ by mitochondria serves as a regulator of a number of important cellular functions, including energy metabolism, cytoplasmic Ca2+ signals, and apoptosis. Recent findings reveal that the process of Ca2+ uptake by the mitochondrial uniporter is itself regulated by Ca2+ in a temporally complex manner.