کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2045328 1073475 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex-Peptide-Regulated Female Sexual Behavior Requires a Subset of Ascending Ventral Nerve Cord Neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Sex-Peptide-Regulated Female Sexual Behavior Requires a Subset of Ascending Ventral Nerve Cord Neurons
چکیده انگلیسی

SummaryBackgroundMale-derived Sex-peptide (SP) elicits egg laying and rejection of courting males in mated Drosophila females. Little is known about the genes that specify the underlying neuronal circuits and mediate this switch in female sexual behavior.ResultsHere we show that the egghead gene involved in glycosphingolipid biosynthesis provides an essential component to the SP response. We have isolated viable alleles of the vital egghead gene that abolish egghead expression from a distal promoter resulting in the absence of the largest transcript of this complex transcription unit. Temporally and spatially restricted expression of egghead revealed a requirement for egghead early in the development of apterous-expressing ventral nerve cord neurons to rescue the SP response. In viable egghead alleles, these ascending interneurons, three per abdominal and seven per thoracic hemisegment, fail to innervate the central brain. egghead expression in apterous neurons rescues neuronal targeting and the response to SP. Furthermore, neurotransmission in apterous neurons is required to elicit the SP response.ConclusionTogether with the former finding of SP binding to afferent nerves 1 and 2, these results suggest that SP-mediated modification of sensory input switches female sexual behavior from the virgin to the mated state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 16, Issue 18, 19 September 2006, Pages 1771–1782
نویسندگان
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