کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2045619 | 1073496 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila](/preview/png/2045619.png)
SummaryApparent defects in cell polarity are often seen in human cancer 1 and 2. However, the underlying mechanisms of how cell polarity disruption contributes to tumor progression are unknown. Here, using a Drosophila genetic model for Ras-induced tumor progression, we show a molecular link between loss of cell polarity and tumor malignancy. Mutation of different apicobasal polarity genes activates c-Jun N-terminal kinase (JNK) signaling and downregulates the E-cadherin/β-catenin adhesion complex, both of which are necessary and sufficient to cause oncogenic RasV12-induced benign tumors in the developing eye to exhibit metastatic behavior. Furthermore, activated JNK and Ras signaling cooperate in promoting tumor growth cell autonomously, as JNK signaling switches its proapoptotic role to a progrowth effect in the presence of oncogenic Ras. Our finding that such context-dependent alterations promote both tumor growth and metastatic behavior suggests that metastasis-promoting mutations may be selected for based primarily on their growth-promoting capabilities. Similar oncogenic cooperation mediated through these evolutionarily conserved signaling pathways could contribute to human cancer progression.
Journal: - Volume 16, Issue 11, 6 June 2006, Pages 1139–1146