Axis formation in Arabidopsis - transcription factors tell their side of the story

► Transcriptional networks emerge as drivers of axis formation. ► WRKY, RWP-RK, and WOX factors establish embryonic polarity with the first division. ► Shoot and root master regulators are separated by miRNAs and the repressor TPL. ► A GATA factor coordinately affects the expression of auxin efflux transporters.