کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2046879 1073834 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural and functional insights into core ABA signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Structural and functional insights into core ABA signaling
چکیده انگلیسی

A series of papers in the last year reported major advances in our understanding of abscisic acid (ABA) signaling: the identification of soluble ABA receptors, the elucidation of a core ABA signaling pathway and structural insights into the mechanism of ABA perception and signaling. Here we summarize these advances, which have shown in atomic resolution that the ABA receptors PYR1, PYL1 and PYL2 function as allosteric switches that inhibit type 2C protein phosphatases (PP2Cs) in response to ABA. These receptors function at the apex of a core signaling pathway that regulates ABA responses by controlling SnRK2 kinase activity and the phosphorylation of downstream target proteins such as ABFs, which control nuclear responses, and the ion channel SLAC1, which mediates electrophysiological responses to ABA.

Figure optionsDownload high-quality image (89 K)Download as PowerPoint slideResearch highlights▶ ABA signaling is controlled by soluble ABA receptors. ▶ ABA receptors PYR1, PYL1 and PYL2 are allosteric switches controlled by ABA binding. ▶ PYR/PYL receptors inhibit PP2C phosphatases, which leads to activation of SnRK2 kinases. ▶ SnRK2s phosphorylate downstream target proteins to regulate ABA responses. ▶ The ABA signaling pathway has been reconstituted in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Plant Biology - Volume 13, Issue 5, October 2010, Pages 495–502
نویسندگان
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