کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2047440 1073975 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functionality of Class A and Class B J-protein co-chaperones with Hsp70
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Functionality of Class A and Class B J-protein co-chaperones with Hsp70
چکیده انگلیسی
At their C-termini, cytosolic Hsp70s have an EEVD tetrapeptide that interacts with J-protein co-chaperones of the B, but not A, class. This interaction is required for partnering with yeast B-type J-proteins in protein folding. Here we report conservation of this feature. Human B-type J-proteins also have a stringent EEVD requirement. Human A-type J-proteins function less well than their yeast orthologs with Hsp70ΔEEVD. Changes in the zinc binding domain, a domain absent in B-type J-proteins, overcomes this partial EEVD dependence. Our results suggest that the structurally similar A- and B-class J-proteins of the cytosol have evolved conserved, yet distinct, features that enhance specialized functionality of Hsp70 machinery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 19, Part B, 14 September 2015, Pages 2825-2830
نویسندگان
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