MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer

• miR-410 expression is increased in non-small cell lung cancer.
• miR-410 promoted non-small cell lung cancer cells proliferation and invasion.
• miR-410 inhibitor inhibited non-small cell lung cancer cells proliferation and invasion.
• BRD7 is the direct target for miR-410.
• miR-410 induces cell proliferation in the AKT-dependent pathway.

miR-410 acts as an oncogene or tumor suppressor gene in some malignancies. However, its role in NSCLC is still unknown. In this study, we showed that the expression of miR-410 was up-regulated in both human NSCLC tissues and cells. Overexpression of miR-410 promoted cell proliferation, migration, and invasion of NSCLC. In addition, bromodomain-containing protein 7 (BRD7) was a direct target of miR-410. MiR-410-mediated downregulation of BRD7 led to increase Akt phosphorylation. Inhibition of Akt phosphorylation can rescue the effect of miR-410 on NSCLC cell. The expression of BRD7 was downregulated in NSCLC and was inversely expressed with miR-410 in NSCLC. Our data provided new knowledge regarding the role of miR-410 in the lung cancer progression.