کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2047509 1073984 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Putative tumor suppression function of SIRT6 in endometrial cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Putative tumor suppression function of SIRT6 in endometrial cancer
چکیده انگلیسی


• The expression of SIRT6 negatively affects the proliferation of endometrial cancer cells.
• SIRT6 induces apoptosis, and its induction is attributed to the repression of survivin.
• The SIRT6 downstream gene survivin could be a novel target for endometrial cancer treatment.

SIRT6, a member of the sirtuin family, has been identified as a candidate tumor suppressor. To pursue the role of SIRT6 in endometrial cancer, we investigated the anti-tumorigenic function of SIRT6. The expression of SIRT6 negatively affected the proliferation of AN3CA and KLE endometrial cancer cells. Increased expression of SIRT6 resulted in the induction of apoptosis by repressing the expression of the anti-apoptotic protein survivin. Consistent with this result, a survivin inhibitor YM155 efficiently inhibited cellular proliferation and induced apoptosis. These results revealed that SIRT6 might function as a tumor suppressor of endometrial cancer cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 17, 4 August 2015, Pages 2274–2281
نویسندگان
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