کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2047533 1073989 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A-to-I editing on tRNAs: Biochemical, biological and evolutionary implications
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
A-to-I editing on tRNAs: Biochemical, biological and evolutionary implications
چکیده انگلیسی

Inosine on transfer RNAs (tRNAs) are post-transcriptionally formed by a deamination mechanism of adenosines at positions 34, 37 and 57 of certain tRNAs. Despite its ubiquitous nature, the biological role of inosine in tRNAs remains poorly understood. Recent developments in the study of nucleotide modifications are beginning to indicate that the dynamics of such modifications are used in the control of specific genetic programs. Likewise, the essentiality of inosine-modified tRNAs in genome evolution and animal biology is becoming apparent. Here we review our current understanding on the role of inosine in tRNAs, the enzymes that catalyze the modification and the evolutionary link between such enzymes and other deaminases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 23, 28 November 2014, Pages 4279–4286
نویسندگان
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