کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2047634 1074006 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Desulfovibrio desulfuricans isolates from the gut of a single individual: Structural and biological lipid A characterization
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Desulfovibrio desulfuricans isolates from the gut of a single individual: Structural and biological lipid A characterization
چکیده انگلیسی


• Microdiversity was shown in two Desulfovibrio strains in a single human gut.
• The first full characterization of the corresponding lipid A structures is realized.
• Cytokines production varied with the different structures.

The levels of sulfate-reducing bacteria (SRB), including Desulfovibrionaceae, in the gut increase following a fat-enriched diet. Endotoxins from gut microbiota contribute to the inflammation process, leading to metabolic diseases. Thus, we sought to characterize the lipid A structures of Desulfovibrionaceae lipopolysaccharides (LPS) that are associated with the microbiota inflammatory properties. LPS variants were obtained from two SRB isolates from the gut of a single individual. These LPS variants shared similar lipid A moieties with Enterobacterial LPS, but differed from one another with regard to fatty-acid numbers and endotoxic activity. This first complete structural characterization of Desulfovibrio lipid A gives new insights into previously published data on Desulfovibrio lipid A biosynthesis. LPS microdiversity within SRBs illustrates how adaptation can influence pro-inflammatory potential.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 1, 2 January 2015, Pages 165–171
نویسندگان
, , , ,