کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2047867 1074039 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers
چکیده انگلیسی

The dengue virus membrane (M) protein is a key component of the mature virion. Here, we characterised the cellular behaviour of M using a recombinant protein construct to understand its inherent properties. Using confocal microscopy, we showed that M and its intracellular precursor, prM, localised to the endoplasmic reticulum. M protein was also detected on the cell surface and secreted, suggesting that M can enter the secretory pathway. In addition, cross-linking studies showed that M can form dimers and tetramers. These findings suggest that M behaves as a secretory protein analogous to the major envelope protein E.


► Dengue virus PrM and M proteins localise to the endoplasmic reticulum.
► M is secreted from the cells while PrM is not.
► M is able to oligomerize into dimers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 7, 5 April 2012, Pages 1032–1037
نویسندگان
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