کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2047911 | 1074045 | 2013 | 6 صفحه PDF | دانلود رایگان |

• Ankrd17 binds human Nod2.
• Nod1- and Nod2-mediated NF-kappa B activation depends on Ankrd17.
• Ankrd17 contributes to bacterial induced innate immune responses in HeLa cells.
Innate immune responses induced by the pattern-recognition receptors Nod1 and Nod2 play pivotal roles to combat infection and to instruct adaptive immunity. Here we identify Ankrd17 as a novel binding partner of Nod2 and show that its N-terminal domain mediates Nod2 binding. Knock-down and overexpression analysis revealed that Ankrd17 is functionally involved in Nod2- and Nod1-mediated responses in human myeloid and epithelial cells. In HeLa cells Ankrd17 contributed to pro-inflammatory responses induced by Shigella flexneri, however not to type I interferon responses induced by Sendai virus. In conclusion, this reveals a novel function for Ankrd17 in anti-bacterial innate immune pathways.
Structured summary of protein interactionsNOD2 and Ankrd17colocalize by fluorescence microscopy (View interaction)
Journal: FEBS Letters - Volume 587, Issue 14, 11 July 2013, Pages 2137–2142