کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048149 1074066 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Translational application of epigenetic alterations: Ovarian cancer as a model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Translational application of epigenetic alterations: Ovarian cancer as a model
چکیده انگلیسی
Cancer is a disease initiated and driven by the accumulation and interplay of genetic and epigenetic mutations of genes involved in the regulation of cell growth and signaling. Dysregulation of these genes and pathways in a cell leads to a growth advantage and clonal expansion. The epigenetic alterations involved in the initiation and progression of cancer are DNA methylation and histone modifications which interact to remodel chromatin, as well as RNA interference. These alterations can be used as candidate targets in molecular tests for risk, early detection, prognosis, prediction of response to therapy, and monitoring, as well as new therapeutic targets in cancer. In this review, we discuss the rationale, studies to date, and issues in the translational application of epigenetics using epithelial ovarian cancer as a specific example of all types of cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 13, 7 July 2011, Pages 2112-2120
نویسندگان
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