کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048224 1074071 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
4′-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
4′-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis
چکیده انگلیسی

Sterol regulatory element-binding proteins (SREBPs) are major transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here we show that 4′-hydroxyflavanone (4′-HF) impairs the fatty acid synthase promoter activity and reduces the activation of SREBPs and their target gene expression in human hepatoma Huh-7 cells. Moreover, 4′-HF suppresses de novo fatty acid and cholesterol synthesis. This study identifies 4′-HF as an inhibitor of SREBP maturation and lipid synthesis, and provides evidence that 4′-HF may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia.


► 4′-HF reduces the activation of SREBP and their target gene expression.
► 4′-HF suppresses de novo fatty acid and cholesterol synthesis.
► 4′-HF may have major potential as a pharmaceutical preparation against steatosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 13, 21 June 2012, Pages 1778–1782
نویسندگان
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