کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048268 1074074 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emerging new roles of the pre-Golgi intermediate compartment in biosynthetic-secretory trafficking
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Emerging new roles of the pre-Golgi intermediate compartment in biosynthetic-secretory trafficking
چکیده انگلیسی

The intermediate compartment (IC) between the endoplasmic reticulum (ER) and the Golgi apparatus appears to constitute an autonomous organelle composed of spatially and functionally distinct, but interconnected, vacuolar and tubular subdomains. In mammalian cells the IC network is stably anchored at the cell center, communicating directly with the endocytic pathway via a pericentrosomal membrane system (PCMS). This finding suggests that the secretory pathway divides at the level of the IC, which functions as a sorting station both in Golgi-dependent and -independent trafficking. The tubular subdomain of the IC is capable of expansion in accordance with its proposed biosynthetic functions such as cholesterol synthesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 23, 3 December 2009, Pages 3804–3810
نویسندگان
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