کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048297 1074075 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Knockdown of von Hippel–Lindau protein decreases lung cancer cell proliferation and colonization
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Knockdown of von Hippel–Lindau protein decreases lung cancer cell proliferation and colonization
چکیده انگلیسی

Although von Hippel–Lindau protein (pVHL) is known as a tumor suppressor in kidney and other organs, it remains unclear whether pVHL plays a role in lung cancer development. We investigated the role of pVHL in lung cancer cell proliferation, migration, and colonization using stable A549 cells with knockdown of pVHL. We found that knockdown of pVHL promotes epithelial-mesenchymal transition (EMT) in lung cancer cells. Knockdown of pVHL decreased tumor colonization in a tail-vein injection model and decreased cell proliferation, whereas overexpression of constitutive active HIF increased tumor colonization, suggesting a HIF-independent function of pVHL in lung. Knockdown of pVHL decreased phosphorylation of FAK and expression of integrin, suggesting that pVHL regulates lung cancer development via integrin/FAK signaling pathway.


► Knockdown of pVHL decreases lung cancer cell proliferation and colonization.
► Knockdown of pVHL promotes lung cancer cell epithelial-mesenchymal transition,migration, and invasion.
► Knockdown of pVHL decreases integrin/FAK signaling in lung cancer cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 586, Issue 10, 21 May 2012, Pages 1510–1515
نویسندگان
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