Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; HA, hyaluronic acid; ECM, extracellular matrix; HNF4α, hepatocyte nuclear factor 4; FAK, focal adhesion kinase; ILK, integrin-linked kinase; CDC42, cell division control protein 42; Rac1, Ras-related C3 botulinum toxin substrate; RhoA, Ras homolog family
مقالات ISI کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2 (ترجمه نشده)
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Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; ActB, β-actin; Akt, protein kinase B; COX2, cyclooxygenase 2; ERK, extracellular signal-regulated kinase; FAK, focal adhesion kinase; GPx, glutathione peroxidase; IκBα, NF-κB inhibitor α; JNK, c-Jun N-terminal kinase; MDA, malondialdehyde; NF-κB, nuclear
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; Collagen; Hypoxia; Xenobiotics; Breast density; Focal adhesion kinase (FAK)AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; DFOM, deferoxamine mesylate salt; ECM, extracellular matrix; FAK, focal adhesion kinase; HD, high density; HIF, hypo
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CAT, catalase; FAK, focal adhesion kinase; H2O2, hydrogen peroxide; MMP, matrix metalloproteinase; Nox, NADPH oxidase; p130cas, Crk-associated substrate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; PTEN, phosphatase and tensin homolog; PTP, protein
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; AAA, abdominal aortic aneurysm; AD, atopic dermatitis; AHR, airway hyperresponsiveness; BMDC, bone marrow-derived cell; CSC, cancer stem cell; ECM, extracellular matrix; FAK, focal adhesion kinase; IPF, idiopathic pulmonary fibrosis; LOX, lysyl oxidase; M
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; cAMP, cyclic AMP; EGF(R), epidermal growth factor (receptor); EMT, epithelial to mesenchymal transition; FITC, fluorescein isothiocyanate; FAK, focal adhesion kinase; GPCR, G protein-coupled receptor; mAb, monoclonal antibody; PI3, phosphatidyl-inositide
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; HA, hydroxyapatite; PCL, poly(ε-caprolactone); PLA, poly(lactic acid); PGA, poly(glycolic acid); PLGA, poly(lactic-co-glycolic acid); SBF, simulated body fluid; PBS, phosphate-buffered saline; SMCs, smooth muscle cells; FAK, focal adhesion kinase; pFAK, p
The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; 3′UTR, 3′untranslational region; ABI, applied biosystem step one; AFP, α fetoprotein; AJCC/UICC, the American Joint Committee on Cancer and International Union against Cancer; AUC, area under curve; FAK, focal adhesion kinase; HBV, hepatitis B virus; HCC,
Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; ADAMTS, A disintegrin and metalloproteinase with thrombospondin motif; AF, Annulus fibrosus; CEP, Cartilaginous end plate; CCN2, Connective tissue growth factor; FAK, Focal adhesion kinase; HIF, Hypoxia inducible factor; HSPG, Heparan-sulphate proteoglyca
(7R,8S)-9-Acetyl-dehydrodiconiferyl alcohol inhibits inflammation and migration in lipopolysaccharide-stimulated macrophages
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; (7R,8S)-9-Acetyl-dehydrodiconiferyl alcohol; Lipopolysaccharide; Raw264.7; Inflammation; Migration; SrcADDA, (7R,8S)-9-acetyl-dehydrodiconiferyl alcohol; COX-2, cyclooxygenase-2; FAK, focal adhesion kinase; iNOS, inducible nitric oxide synthase; l-NMMA, N
β3 integrin promotes chemoresistance to epirubicin in MDA-MB-231 through repression of the pro-apoptotic protein, BAD
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; ABC transporters, ATP binding cassette transporters; Ct, Cycle threshold; ECM, Extracellular matrix; FAK, Focal Adhesion kinase; GSH, Glutathione; ILK, Integrin linked kinase; PI, Propidium iodide; ROS, Reactive Oxygen species; T-ALL, T cell acute lymphob
Efficiency of calcium phosphate composite nanoparticles in targeting Ehrlich carcinoma cells transplanted in mice
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; EAC, Ehrlich Ascites Carcinoma; Nano-CaP, nano calcium phosphate; GABA, gamma aminobutyric acid; 5HT, serotonin; 8-OHDG, 8-hydroxy-deoxyguanosine; ATP, adenosine triphosphate; IP, intraperitoneal; IT, intratumoral; FAK, focal adhesion kinase; DNA, deoxyri
Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; 2-APB, 2-aminoethoxydiphenyl borate; ATP, adenosine 5′-triphosphate; BBG, Brilliant Blue G; EGTA, ethylene glycol tetraacetic acid; ER, endoplasmic reticulum; ECM, extracellular matrix; FAs, focal adhesions; FAK, focal adhesion kinase; FBS, fetal bovine s
Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; bFGF, basic fibroblast growth factor; CuB, Cucurbitacin B; CAM, chorioallantoic membrane; ECM, extracellular matrix; FAK, focal adhesion kinase; HUVECs, human umbilical vein endothelial cells; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium brom
α integrin targeting for radiosensitization of three-dimensionally grown human head and neck squamous cell carcinoma cells
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; 3D, three-dimensional; 2D, two-dimensional; siRNA, small interfering RNA; HNSCC, head and neck squamous cell carcinoma; FAK, focal adhesion kinase; lrECM, laminin-rich extracellular matrix; IP, immunoprecipitationα3 integrin; β1 integrin; Head and neck ca
Effects of cilengitide in osteoclast maturation and behavior
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; ECM, extracellular matrix; PTKs, protein-tyrosine kinases; FAK, focal adhesion kinase; SFKs, Src-family PTKs; RGD, arginine-glycine-aspartic acid; vWF, von Willebrand factor; CSF-1, colony–stimulating factor-1; RANKL, receptor activator of nuclear factor
α5-Integrin-mediated cellular signaling contributes to the myogenic response of cerebral resistance arteries
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; FAK, focal adhesion kinase; FI-14, FAK inhibitor 14; LC20, 20 kDa myosin regulatory light chains; MHC class I, major histocompability complex class I; MLCK, myosin light chain kinase; MLCP, myosin light chain phosphatase; MYPT1, MLCP targeting subunit; Ph
Selective targeting of FAK–Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; α-Naphthoflavone; Doxorubicin; Chemotherapeutic resistance; Breast cancer; Focal adhesion kinaseANF, alpha-naphthoflavone; BCa, breast cancer; CI, combination index; Cy, cyanine; DMSO, dimethyl sulfoxide; Dox, doxorubicin; FAK, focal adhesion kinase; P-gp
A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CCID, circular chemo repellent-induced defect; CDK, cyclin dependent kinase; DME, dichloromethane extract (of P. odorata); FAK, focal adhesion kinase; HL-60, human promyelocytic leukaemia cells; HOPi, Hoechst 33258/propidium iodide double staining; HRP, h
CD99 inhibits CD98-mediated β1 integrin signaling through SHP2-mediated FAK dephosphorylation
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; SHP2, Src homology region 2 domain-containing phosphatase-2; FAK, focal adhesion kinase; PKC, protein kinase C; ILK, integrin-linked kinase; IPP, ILK–PINCH–parvin; Akt1, protein kinase B; FA, focal adhesions; SCLC, small cell lung-cancer cell line; LFA-1,
Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; FAK, focal adhesion kinase; FAT, focal adhesion targeting; sAB, synthetic antibody; CDR, complementarity-determining region; MBP, maltose binding protein; SPR, surface plasmon resonance; ASU, asymmetric unit; PEG, polyethylene glycol; PMP, paramagnetic pa
PTK2b function during fertilization of the mouse oocyte
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; IVF, in vitro fertilization; PTK, protein tyrosine kinase; MII, metaphase-II; FAK, focal adhesion kinase; PYK2, protein tyrosine kinase-2b; SFK, Src-Family kinase; mKSOMAA, modified potassium simplex-optimized medium with amino acids; BSA, bovine serum al
Left Ventricular Noncompaction : A Distinct Cardiomyopathy or a Trait Shared by Different Cardiac Diseases?
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; compacted; epidemiology; genetics; imaging; pathology; trabeculaeARVC, arrhythmogenic right ventricular cardiomyopathy; CMR, cardiac magnetic resonance; DCM, dilated cardiomyopathy; FAK, focal adhesion kinase; HCM, hypertrophic cardiomyopathy; ICD, implan
Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21Cip1
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CDK, cyclin-dependent kinase; CDKI, cyclin-dependent kinase inhibitor; DOX, doxorubicin; FAK, focal adhesion kinase; MFKO, myocyte-restricted FAK knockout mice; NRCMs, neonatal rat cardiomyocytes; NTG, non-transgenic littermate control mice; SF, Super act
Cell cycle arrest or survival signaling through αv integrins, activation of PKC and ERK1/2 lead to anoikis resistance of ovarian cancer spheroids
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; ECM, extracellular matrix; ER, endoplasmic reticulum; ERK1/2, extracellular signal-regulated kinase 1/2; FAK, focal adhesion kinase; MAPK, mitogen-activated protein kinase; Mcl-1, myeloid cell leukemia sequence 1; PARP, poly(ADP-ribose) polymerase; PI3k,
Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; AR, androgen receptor; ARA55, androgen receptor-associated protein of 55 kDa; CAFs, cancer associated fibroblasts; DHT, 5α-dihydrotestosterone; ECM, extracellular matrix; FA, focal adhesion; FAK, focal adhesion kinase; GR, glucocorticoid receptor; LBD, li
Overexpression of enhancer of zeste homolog 2 (EZH2) and focal adhesion kinase (FAK) in high grade endometrial carcinoma
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; EZH2, enhancer of zeste homolog 2; FAK, focal adhesion kinase; AJCC, American Joint Committee on CancerDeregulation of EZH2, FAK and pFAK; Endometrial carcinoma; Histology subtype; Potential therapeutic targets for treatment
The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; ECM, extracellular matrix; ERK, extracellular signal-regulated kinase; FAK, focal adhesion kinase; FPCL, fibroblast-populated collagen lattice; ILK, integrin-linked kinase; KO, knockout; MCP-1, monocyte chemoattractant protein-1; NPWT, negative pressure w
The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; HCC, hepatocellular carcinoma; SphK1, sphingosine kinase 1; S1P, sphingosine 1-phosphate; S1PR1-5, S1P receptor type1-5; CI, combination index; Fa, fraction affected; FAK, focal adhesion kinase; MLC-2, myosin light chains-2Sphingosine kinase 1; ERK; N-ras
Semaphorin7A and its receptors: Pleiotropic regulators of immune cell function, bone homeostasis, and neural development
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CDn, cluster of differentiation n; CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; ECM, extracellular matrix; ERF, Ets2-repressor factor; FAK, focal adhesion kinase; GAP, GTPase activating protein; GPI, glycosylphosphatidylino
Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; Actin remodeling; Cell matrix; Cell adhesion; Hypoxia; Radiation; Stress fibersCGM, complete growth medium; FAK, focal adhesion kinase; Erk, extracellular signal regulated kinase; FBS, fetal bovine serum; GA, geldanamycin; IR, ionizing radiation; Hsp, hea
Carbon nanotubes in neuroregeneration and repair
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CNS, central nervous system; DRG, dorsal root ganglia; ECM, extracellular matrix; EN, ethylenediamine; ERK, extracellular signal-regulated kinase; FAK, focal adhesion kinase; fwCNT, few-walled CNT; KCC2, potassium chloride cotransporter 2; LBL, layer-by-l
Biomechanical force in blood development: Extrinsic physical cues drive pro-hematopoietic signaling
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; ADAM, a disintegrin and metalloprotease; AGM, aorta-gonad-mesonephros; CaSR, calcium sensing receptor; CXCR, chemokine C-X-C motif receptor; DAG, diacylglycerol; Dll, delta-like; ECM, extracellular matrix; FA, focal adhesion; FAK, focal adhesion kinase; F
Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CM, culture medium; COX, cyclooxygenase; CRC, colorectal cancer; ECM, extracellular matrix; FA, focal adhesion; FAK, focal adhesion kinase; HNPCC, Hereditary nonpolyposis colorectal cancer; MSI, microsatellite instable; MMP, Matrix metalloproteinase; MSS,
Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; cIAP-1, Cellular inhibitor of apoptosis protein-1; COX-2, cyclooxygenase-2; CREB, cAMP response element-binding; C-X-C motif, chemokine; EBV, Epstein-Barr virus; ERK, Extracellular signal-regulated kinase; FAK, focal adhesion kinase; HTLV, human lymphotro
Knockdown of von Hippel–Lindau protein decreases lung cancer cell proliferation and colonization
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; pVHL, von Hippel–Lindau protein; EMT, epithelial-mesenchymal transition; NSCLC, non-small cell lung cancer; HIF, hypoxia inducible factor; FAK, focal adhesion kinase; FBS, fetal bovine serum; shRNAs, small hairpin RNAs; α-SMA, α-mooth muscle actinFocal ad
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; PD, Parkinson’s disease; HSC70, heat shock cognate 70; PTP1B, protein tyrosine phosphatase 1B; FAK, focal adhesion kinase; UPS, Ubiquitin–proteasomal system; CLS, Chaperone–lysosomal system; CMA, chaperone-mediated autophagy; PQ, paraquatα-Synuclein; Phos
Regeneration and bioengineering of the gastrointestinal tract: Current status and future perspectives
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; BMP, bone morphogenic protein; FAK, focal adhesion kinase; ECM, extracellular matrix; PLA, poly-l-lactic acid; PGA, polyglycolic acid; PCL, poly e-caprolactone; IAS, internal anal sphincterDevelopment; Extracellular matrix; Regenerative medicine; Scaffold
Integrins in mammary development
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; BLG, β-lactoglobulin; ECM, extracellular matrix; FAK, focal adhesion kinase; ILK, integrin-linked kinase; JAK2, Janus-activated kinase 2; JNK, Jun NH2-terminal kinase; MAPK, mitogen activated protein kinase; MMTV, mouse mammary tumor virus; P130Cas, p130
Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; Ang II, angiotensin II; BSA, bovine serum albumin; CF, cardiac fibroblasts; ECM, extracellular matrix; FAK, focal adhesion kinase; FBS, fetal bovine serum; FPP, farnesylpyrophosphate; GGPP, geranylgeranyl pyrophosphate; HMG-CoA, 3-hydroxy 3-methylglutaryl
Dickkopf-1 (DKK-1) interrupts FAK/PI3K/mTOR pathway by interaction of carbonic anhydrase IX (CA9) in tumorigenesis
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; DKK-1, dickkopf-1; CA9, carbonic anhydrase IX; HUVEC, human umbilical vein endothelial cell; VEGF, vascular endothelial growth factor; FAK, focal adhesion kinase; mTOR, mammalian target of rapamycin; ONPG, o-nitrophenyl β-d-galactopyranosideAngiogenesis;
Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; APC, antigen presenting cell; BCR, B cell receptor; FAK, focal adhesion kinase; ICAM-1, intercellular adhesion molecule-1; LFA-1, lymphocyte function-associated antigen-1 (αLβ2 integrin); MZ, marginal zone; PI3K, phosphoinositide 3-kinase; P-Akt, phospho-
AT2 receptors recruit c-Src, SHP-1 and FAK upon activation by Ang II in PND15 rat hindbrain
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; Ang II, angiotensin II; CREB, cAMP response element-binding; FAK, focal adhesion kinase; IGFR, insulin-like growth factor receptor; MAPK, mitogen-activated protein kinase; MKP-1, MAPK phosphatase-1; PND, post-natal day; PC, Purkinje cell; PTK, protein tyr
Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; Organoselenium-saccharide derivative; Ebselen; Cancer; Invasion; MetastasisBSZ, benzisoselenazolone fragment; FA, focal adhesion; FAK, focal adhesion kinase; PKC-α, protein kinase C
Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical cancer by modulating phosphorylated prohibitin in lipid rafts
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; Akt, serine/threonine-specific protein kinase; DMEM, Dulbecco’s modified Eagle’s medium; ERK, extracellular signal-regulated kinases; FAK, focal adhesion kinase; FBS, fetal bovine serum; FMDV, foot-and-mouth disease virus; H&E, hematoxylin and eosin; IC50
The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CCK, COOH-terminal octapeptide of cholecystokinin; TPA, 12-O-tetradecanoylphorbol-13-acetate; SFK, Src family of kinases; PKC, protein kinase C; PYK2, proline-rich tyrosine kinase 2; FAK, focal adhesion kinase; SHC, Src homology 1 domain containing transf
JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; JNK, c-jun N-terminal kinase; FAK, focal adhesion kinase; EGF, epithelial growth factor; THCE, SV40-immortalized human corneal epithelial; RNAi, RNA interference.Cell migration; JNK; Paxillin; FAK
Synthesis and biological evaluation of tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; FAK, focal adhesion kinase; FBS, fetal bovine serum; GALT, gut-associated lymphoid tissues; GVHD, graft-versus-host disease; HBSS, Hank’s buffered salt solution; HMP, linker 4-(hydroxymethyl)phenoxyacetic acid; iIEL, intestinal intraepithelial lymphocytes
Focal Adhesion Kinase Regulation of Mechanotransduction and its Impact on Endothelial Cell Functions
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; CTF, cell traction force; EC, Endothelial Cell; ECM, Extracellular matrix; FA, Focal adhesion; FAK, Focal adhesion kinase; FERM, band 4.1 Ezrin, Fadixin, Moesin homology; FAT, Focal Adhesion Targeting; FSS, Fluid shear stress; Grb2, Growth factor receptor
Involvement of SHP2 in focal adhesion, migration and differentiation of neural stem cells
Keywords: کیناز چسبندگی موضعی، پروتئین تیروزین کیناز2; FA, focal adhesion; FAK, focal adhesion kinase; NS, Noonan Syndrome; PTP4, protein tyrosine phosphatase IV; SHP2, Src-homology-2 domain-containing protein tyrosine phosphataseSHP2; Phosphatase; Neural stem cells; Differentiation; Adhesion; Migration