کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048331 | 1074076 | 2012 | 7 صفحه PDF | دانلود رایگان |
Hypoxic preconditioning (HP) is an evolutionarily-conserved mechanism that protects an organism against stress. The mitochondrial ATP-sensitive K+ channel (mKATP) plays an essential role in the protective signaling, but remains molecularly undefined. Several lines of evidence suggest that mKATP may arise from an inward rectifying K+ channel (Kir). The genetic model organism Caenorhabditis elegans exhibits HP and displays mKATP activity. Here, we investigate the tissue expression profile of the three C. elegans Kir genes and demonstrate that mutant strains where the irk genes have been deleted either individually or in combination can be protected by HP and exhibit robust mKATP channel activity in purified mitochondria. These data suggest that the mKATP in C. elegans does not arise from a Kir derived channel.
► A mitochondrial KATP channel (mKATP) is central to ischemic preconditioning (IPC).
► A Kir family member is thought to form the mKATP.
► C. elegans benefit from IPC and display mKATP activity.
► Kir genes in worms are not required for IPC or mKATP.
Journal: FEBS Letters - Volume 586, Issue 4, 17 February 2012, Pages 428–434