کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048353 | 1074077 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Up-regulation of calsyntenin-3 by β-amyloid increases vulnerability of cortical neurons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Up-regulation of calsyntenin-3 by β-amyloid increases vulnerability of cortical neurons Up-regulation of calsyntenin-3 by β-amyloid increases vulnerability of cortical neurons](/preview/png/2048353.png)
چکیده انگلیسی
β-Amyloid (Aβ) may play an important role in the pathogenesis of Alzheimer’s disease. However, a causal relationship between Aβ oligomers and layer-specific neurodegeneration has not been clarified. Here we show up-regulation of calsyntenin (Cst)-3 in cultured neurons treated with Aβ oligomers and in Tg2576 mice. Cst-3 is distributed in large neurons in layers 2–3 and 5 of the cerebral cortex, and accumulated in dystrophic neurites surrounding Aβ-plaques. Overexpression of Cst-3 accelerates neuronal death. These results indicate that up-regulation of Cst-3 in cortical neurons in layers 2–3 and 5 by Aβ oligomers may lead to increase in vulnerability of neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 4, 18 February 2011, Pages 651–656
Journal: FEBS Letters - Volume 585, Issue 4, 18 February 2011, Pages 651–656
نویسندگان
Yoko Uchida, Shun-ichirou Nakano, Fujiya Gomi, Hiroshi Takahashi,