کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048356 | 1074077 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Control of RNA processing by a large non-coding RNA over-expressed in carcinomas
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Control of RNA processing by a large non-coding RNA over-expressed in carcinomas Control of RNA processing by a large non-coding RNA over-expressed in carcinomas](/preview/png/2048356.png)
چکیده انگلیسی
RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not fully established. Σ RNA is a class of conserved large non-coding RNAs (murine Hepcarcin; human MALAT-1) up-regulated in carcinomas. Using antisense technology, we identified that RNA post-transcriptional modification is the most significant global function of Σ RNA. Specifically, processing of the pre-mRNAs of genes including Tissue Factor and Endoglin was altered by hydrolysis of Σ RNA/MALAT-1. These results support the hypothesis that Σ RNA/MALAT-1 is a regulatory molecule exerting roles in RNA post-transcriptional modification.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 4, 18 February 2011, Pages 671–676
Journal: FEBS Letters - Volume 585, Issue 4, 18 February 2011, Pages 671–676
نویسندگان
Rui Lin, Manami Roychowdhury-Saha, Chris Black, Andrew T. Watt, Eric G. Marcusson, Susan M. Freier, Thomas S. Edgington,