کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048399 1074079 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heat shock protein 60: Evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Heat shock protein 60: Evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation
چکیده انگلیسی

Adipocytes play important roles in lipid metabolism but also in the control of inflammatory processes. Based on our previous findings of heat shock protein (Hsp) 60-induced activation of preadipocytes we investigated whether the capacity of heat shock protein 60 (Hsp60) to interact with adipocytes and to stimulate their proinflammatory activity is determined by the differentiation state of the cells. Hsp60 bound to adipocytes and stimulated the release of inflammatory mediators independent of their differentiation state. Hsp60-adipocyte interactions revealed basic characteristics of a receptor-mediated process. Our findings characterize Hsp60 binding and Hsp60-induced release of proinflammatory mediators as fundamental properties of adipocytes independent of their differentiation state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 17, 3 September 2009, Pages 2877–2881
نویسندگان
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