کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2048412 | 1074079 | 2009 | 7 صفحه PDF | دانلود رایگان |

Delta-like 1 (Dlk1) is expressed in 3T3-L1 preadipocytes and has frequently been referred to as “the” preadipocyte marker, yet the phenotype of DLK1+ cells in adipose tissue remains undetermined. Herein, we demonstrate that DLK1+ cells encompass around 1–2% of the adult mouse adipose stromal vascular fraction (SVF). Unexpectedly, the DLK1+SVF population was enriched for cells expressing genes generally ascribed to the vascular lineage and did not possess any adipogenic differentiation potential in vitro. Instead, DLK1+ cells comprised an immediate ability for cobblestone formation, generation of tube-like structures on matrigel, and uptake of Acetylated Low Density-Lipoprotein, all characteristics of endothelial cells. We therefore suggest that DLK1+SVF cells are of a vascular origin and not them-selves committed preadipocytes as assumed hitherto.
Journal: FEBS Letters - Volume 583, Issue 17, 3 September 2009, Pages 2947–2953