کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048441 | 1074081 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model](/preview/png/2048441.png)
چکیده انگلیسی
We examined the change of protein tyrosine kinases (PTKs) expression levels in colonic epithelial cells isolated from mice in which colitis was induced by oxazolone administration, using the monoclonal antibody YK34, which cross-reacts with a wide variety of PTKs. We identified focal adhesion kinase (FAK) and found the expression level increased due to the induction of colitis. Furthermore, we found that there was a positive correlation between FAK expression and the severity of colitis. Also, FAK expression localized in the colonic epithelium but not in the lamina propria, implying FAK functions in epithelial cells during colitis formation and/or wound repairing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 18, 24 September 2010, Pages 3949–3954
Journal: FEBS Letters - Volume 584, Issue 18, 24 September 2010, Pages 3949–3954
نویسندگان
Yanju Ma, Shingo Semba, Atsuo Maemoto, Masayuki Takeuchi, Isamu Kameshita, Atsuhiko Ishida, Sanae Kato, Tsuyoshi Katoh, Yunpeng Liu, Takanobu Taniguchi,