کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048639 | 1074086 | 2011 | 5 صفحه PDF | دانلود رایگان |
Green tea’s health benefits have been attributed to its major polyphenols, the catechins: (−)-epigallocatechin gallate (EGCG), (−)-epicatechin gallate (ECG), (−)-epigallocatechin (EGC), and epicatechin (EC). Catechins (especially EGCG) modulate a wide range of biologically important molecules, including many membrane proteins. Yet, little is known about their mechanism(s) of action. We tested the catechins’ bilayer-modifying potency using gramicidin A (gA) channels as molecular force probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency (EGCG > ECG ≫ EGC > EC). Additionally, the gallate group causes current block, as evident by brief downward current transitions (flickers).
► Green tea catechins alter lipid bilayer properties and gramicidin channel function.
► The rank order of the catechins’ effect on bilayer properties is similar to that for their biological effects.
► Gallate group containing molecules interrupt gramicidin channel current.
Journal: FEBS Letters - Volume 585, Issue 19, 3 October 2011, Pages 3101–3105