کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048822 | 1543464 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Detection of infectious prions in urine Detection of infectious prions in urine](/preview/png/2048822.png)
Prions are the infectious agents responsible for prion diseases, which appear to be composed exclusively by the misfolded prion protein (PrPSc). The mechanism of prion transmission is unknown. In this study, we attempted to detect prions in urine of experimentally infected animals. PrPSc was detected in ∼80% of the animals studied, whereas no false positives were observed among the control animals. Semi-quantitative calculations suggest that PrPSc concentration in urine is around 10-fold lower than in blood. Interestingly, PrPSc present in urine maintains its infectious properties. Our data indicate that low quantities of infectious prions are excreted in the urine. These findings suggest that urine is a possible source of prion transmission.
Journal: FEBS Letters - Volume 582, Issues 21–22, 22 September 2008, Pages 3161–3166