کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048861 | 1074104 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo](/preview/png/2048861.png)
چکیده انگلیسی
Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcεRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcεRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcεRI surface expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 1, 4 January 2010, Pages 111–118
Journal: FEBS Letters - Volume 584, Issue 1, 4 January 2010, Pages 111–118
نویسندگان
Natsuko Kageyama-Yahara, Yoko Suehiro, Futoshi Maeda, Shun-ichiro Kageyama, Junya Fukuoka, Tatsuo Katagiri, Takeshi Yamamoto, Makoto Kadowaki,