کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048917 1074106 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells
چکیده انگلیسی

The aim of the present study is to determine the role of intracellular Ca2+ in VEGF signaling. We demonstrate that reduction in Ca2+ by chelating compound BAPTA-AM or by IP3-endoplasmic reticulum blocker 2-APB selectively inhibited VEGF-induced activation of c-Src-PI3K-Akt but not ERK1/2 in human coronary artery endothelial cells (HCAEC). We also show that the selective inhibitory effects of NADPH oxidase knockdown on VEGF-mediated activation of c-Src-PI3K-Akt signaling and cell proliferation in HCAEC can be reversed by increase in intracellular Ca2+. These results suggest an essential role for Ca2+ in redox-dependent selective activation of c-Src-PI3K-Akt and endothelial cell proliferation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3131–3136
نویسندگان
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