کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048927 | 1074106 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
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کلمات کلیدی
NET, neutrophil extracellular trapDPI, diphenylene iodonium - DPI، دیوفنیلن یدونیومEC, endothelial cells - EC، سلول های اندوتلیالIL-8, interleukin 8 - IL-8، اینترلوکین 8PMA, phorbol 12-myristate 13-acetate - PMA، phorbol 12-myristate 13-acetatePMN, polymorphonuclear neutrophil - PMN، نوتروفیل پلی مر و هسته ای
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death](/preview/png/2048927.png)
چکیده انگلیسی
Neutrophil interaction with activated endothelial cells (EC) is required for transmigration. We examined consequences of this interaction on NETosis. Co-culture of activated EC with neutrophils induced neutrophil extracellular trap (NET) formation, which was partially dependent on production of IL-8 by activated EC. Extended neutophil/EC co-culture resulted in EC damage, which could be abrogated by inclusion of either diphenyleneiodonium to inhibit the NAPDH oxidase pathway required for NETosis, or DNAse to disrupt NETs. These findings offer new insight into mechanisms whereby NETs trigger damage to the endothelium in sepsis, small vessel vasculitis and possibly the villous trophoblast in preeclampsia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3193–3197
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3193–3197
نویسندگان
Anurag Kumar Gupta, Manjunath B. Joshi, Maria Philippova, Paul Erne, Paul Hasler, Sinuhe Hahn, Therese J. Resink,