Keywords: PMA، phorbol 12-myristate 13-acetate; COPD, chronic obstructive pulmonary disease; HDAC, histone deacetylase; PMA, phorbol 12-myristate 13-acetate; LPS, lipopolysaccharide; GSH, glutathione; qPCR, quantitative polymerase chain reaction; TNFα, tumor necrosis factor α; 4-HNE, 4-hydroxynonenal;
مقالات ISI PMA، phorbol 12-myristate 13-acetate (ترجمه نشده)
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Keywords: PMA، phorbol 12-myristate 13-acetate; HDP, host defense peptides; OVA, ovalbumin; MRSA, methicillin-resistant Staphylococcus aureus; HBSS, Hank's balanced salt solution; LPS, lipopolysaccharide; IDR, innate defense regulator peptide; PMA, phorbol 12-myristate 13-acetate; DCFDA, 2′,7′-dichloro
Immunosuppressive drugs affect induction of IFNy+ Treg in vitro
Keywords: PMA، phorbol 12-myristate 13-acetate; aTreg, adaptive T regulator cell; nTreg, natural T regulator cell; MLC, mixed lymphocyte culture; FCS, fetal calf serum; PBL, peripheral blood lymphocytes; PBMC, peripheral blood mononuclear cells; PMA, phorbol 12-myristate 13-acetate; Tbet, T-box express
A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway
Keywords: PMA، phorbol 12-myristate 13-acetate; BSA, bovine serum albumin; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; H1R, histamine H1 receptor; IL, interleukin; PKCδ, protein kinase C-δ; PMA, phorbol 12-myristate 13-acetate; R
Verticine, ebeiedine and suchengbeisine isolated from the bulbs of Fritillaria thunbergii Miq. inhibited the gene expression and production of MUC5AC mucin from human airway epithelial cells
Keywords: PMA، phorbol 12-myristate 13-acetate; Airway; Mucin; Verticine; Ebeiedine; SuchengbeisineEGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; PBS, phosphate-buffered saline; PMA, phorbol 12-myristate 13-acetate; RT-PCR, reverse transcription - polymerase chain reaction; TNF
Effects of the antioxidants Trolox, Tiron and Tempol on neutrophil extracellular trap formation
Keywords: PMA، phorbol 12-myristate 13-acetate; OCl−, hypochlorite; OH, hydroxyl radical; O2−, superoxide anion radical; 1O2, singlet oxygen; HOCl, hypochlorous acid; MPO, myeloperoxidase; NETs, neutrophil extracellular traps; PMA, phorbol 12-myristate 13-acetate; PFA, paraformaldehyde; ROS, reactive o
Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps
Keywords: PMA، phorbol 12-myristate 13-acetate; CR3, complement receptor type 3 (CD11b/CD18); DHR, dihydrorhodamine; DIC, differential interference contrast; FH, factor H; Fn, fibronectin; HSA, human serum albumin; NET, neutrophil extracellular trap; PMA, phorbol 12-myristate 13-acetate; ROS, reactive
Zymosan and PMA activate the immune responses of Mutz3-derived dendritic cells synergistically
Keywords: PMA، phorbol 12-myristate 13-acetate; muDC, dendritic cell derived from Mutz-3; NF-κB, nuclear factor kappa B; IκB, Inhibitor of NF-κB; IKK, IκB kinase; TNF-α, tumor necrosis factor alpha; LPS, lipopolysaccharide; PMA, phorbol 12-myristate 13-acetate; DAG, diacylglycerol; EDTA, ethylenediamin
Luteolin 8-C-β-fucopyranoside downregulates IL-6 expression by inhibiting MAPKs and the NF-κB signaling pathway in human monocytic cells
Keywords: PMA، phorbol 12-myristate 13-acetate; PMA, phorbol 12-myristate 13-acetate; PKC, protein kinase C; IL-6, interleukin-6; LU8C-FP, luteolin 8-C-β-fucopyranosideIL-6; Luteolin; PMA; THP-1; Inflammation
Phagocyte interactions with Mycobacterium tuberculosis — Simultaneous analysis of phagocytosis, phagosome maturation and intracellular replication by imaging flow cytometry
Keywords: PMA، phorbol 12-myristate 13-acetate; ADC, albumin dextrose catalase; Ch, channel; EDF, extended depth of field; FITC, fluorescein isothiocyanate; GFP, green fluorescent protein; LAM, lipoarabinomannan; LAMP, lysosome-associated membrane glycoprotein; PMA, phorbol 12-myristate 13-acetate; PBS
A novel disease-causing CD40L mutation reduces expression of CD40 ligand, but preserves CD40 binding capacity
Keywords: PMA، phorbol 12-myristate 13-acetate; CD40L, CD40 ligand; PMA, phorbol 12-myristate 13-acetate; CVID, common variable immunodeficiency; SH2D1A, SH2 domain containing 1A; TACI, tumor necrosis factor receptor superfamily member 13B; BAFF, tumor necrosis factor (ligand) superfamily, member 13b;
Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D3 and deapi-platycodin on production and secretion of airway mucin in vitro
Keywords: PMA، phorbol 12-myristate 13-acetate; Airway mucin; PlatycodinD3; Deapi-platycodinEGF, epidermal growth factor; PBS, phosphate-buffered saline; RT-PCR, reverse transcription-polymerase chain reaction; ELISA, enzyme-linked immunosorbent assay; PMA, phorbol 12-myristate 13-acetate
ZSWIM1: A novel biomarker in T helper cell differentiation
Keywords: PMA، phorbol 12-myristate 13-acetate; SWIM domain; T helper cells; Th17 cells; IL-17A; Th1 cells; InflammationPBMCs, peripheral blood mononuclear cells; ICS, intracellular staining; PMA, phorbol 12-myristate 13-acetate; IFNγ, interferon gamma; qPCR, quantitative Real time polymerase chain rea
The soluble form of HFE protein regulates hephaestin mRNA expression in the duodenum through an endocytosis-dependent mechanism
Keywords: PMA، phorbol 12-myristate 13-acetate; sHFE, soluble HFE; holo-Tf, iron-loaded transferrin; Cybrd1, duodenal cytochrome b; Heph, hephaestin; Fpn1, ferroportin-1; TfR, transferrin receptor; TfSat, transferrin saturation; β2M, beta 2-microglobulin; PMA, phorbol 12-myristate 13-acetate; Dyn, dyna
High density lipoproteins down-regulate transcriptional expression of pro-inflammatory factors and oxidative burst in head kidney leukocytes from rainbow trout, Oncorhynchus mykiss
Keywords: PMA، phorbol 12-myristate 13-acetate; Respiratory burst; Head kidney leukocytes; HDL; LPS; CytokinesROS, reactive oxygen species; HDL, high density lipoprotein; PMA, phorbol 12-myristate 13-acetate; A-SAA, acute serum amyloid A; Asx, astaxanthin
Invariant natural killer T cells are phenotypically and functionally altered in Fabry disease
Keywords: PMA، phorbol 12-myristate 13-acetate; iNKT, invariant natural killer T; α-GalCer, α-galactosylceramide; Gb3, globotriaosylceramide; ERT, enzyme replacement therapy; PMA, phorbol 12-myristate 13-acetate; TCR, T cell receptorLysosomal storage disorders; Fabry disease; Enzyme replacement therapy
Crotonaldehyde-exposed macrophages induce IL-8 release from airway epithelial cells through NF-κB and AP-1 pathways
Keywords: PMA، phorbol 12-myristate 13-acetate; COPD, Chronic obstructive pulmonary disease; MTT, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltertrazoliumbromide; BCA, Bicinchoninic acid; PMA, Phorbol 12-myristate 13-acetate; PDTC, Pyrrolidin dithiocarbamateCrotonaldehyde; IL-8; NF-κB; AP-1; Macrophages;
Protein Kinase C recognition sites in the cytoplasmic domain of Endothelin Converting Enzyme-1c
Keywords: PMA، phorbol 12-myristate 13-acetate; PMA, phorbol 12-myristate 13-acetate; CHO cells, Chinese Hamster Ovary cells; ECE-1, Endothelin Converting Enzyme-1; BigET-1, Big Endothelin-1; ATCC, American Type Culture CollectionEndothelin-1; Endothelin Converting Enzyme-1; Phosphorylation; Enzyme tra
Isolation, expansion and characterisation of alloreactive human Th17 and Th1 cells
Keywords: PMA، phorbol 12-myristate 13-acetate; APCs, antigen presenting cells; pBMCs, peripheral blood mononuclear cells; ICS, intracellular staining; PMA, phorbol 12-myristate 13-acetate; ABS, human AB negative serum; DMSO, dimethyl sulfoxide; IL, interleukin; IFNγ, interferon gammaTh17 cells; IL-17A
A simple reporter assay for screening claudin-4 modulators
Keywords: PMA، phorbol 12-myristate 13-acetate; TJs, tight junctions; C-CPE, the carboxyl terminus of Clostridium perfringens enterotoxin; TGF-β, transforming growth factor-β; EGF, epidermal growth factor; PMA, phorbol 12-myristate 13-acetate; DMSO, dimethyl sulfoxide; PCR, polymerase chain reaction; R
Protein kinase C stimulates human B cell activating factor gene expression through reactive oxygen species-dependent c-Fos in THP-1 pro-monocytic cells
Keywords: PMA، phorbol 12-myristate 13-acetate; BAFF, B cell activating factor belongs to TNF-α family; ROS, reactive oxygen species; FBS, fetal bovine serum; NAC, N-acetyl-L-cysteine; DCF-DA, 2′,7′-Dichlorodihydrofluorescein diacetate; PMA, phorbol 12-myristate 13-acetate; IOM, ionomycinhBAFF; Promote
Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
Keywords: PMA، phorbol 12-myristate 13-acetate; MPP+, 1-methyl-4-phenylpyridinium ion; WST-1, 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium; DPI, diphenyleneiodonium; PD, Parkinson disease; PHOX, phagocyte NADPH oxidase; PMA, phorbol 12-myristate 13-acetate; ROS, reactive oxyg
PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation
Keywords: PMA، phorbol 12-myristate 13-acetate; PKB, protein kinase B; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; IGF, Insulin-like growth factor; PDGF, platelet derived growth factor; PDK-1, Phosphoinositide-dependent kinase-1; PI3K, phosphatidylinositol 3-kinase; shRNA, short hairpi
Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis
Keywords: PMA، phorbol 12-myristate 13-acetate; HERG, human ether-a-go-go-related gene; HEK, human embryonic kidney; PKA, protein kinase A; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; CPT-cAMP, chlorophenylthiol-cyclic-AMP; H89, N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline; Bis-I,
Incomplete activation of human eosinophils via the histamine H4-receptor: Evidence for ligand-specific receptor conformations
Keywords: PMA، phorbol 12-myristate 13-acetate; GPCR, G-protein-coupled receptor; EPO, eosinophil peroxidase; fMLP, N-formyl-l-methionyl-l-leucyl-l-phenylalanine; UR-PI376, 2-cyano-1-[4-(1H-imidazol-4-yl)butyl]-3-[(2-phenylthio)ethyl]guanidine; PMA, phorbol 12-myristate 13-acetate; JNJ7777120, 1-[(5-ch
PKCδ and ε regulate the morphological integrity of the ER–Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus
Keywords: PMA، phorbol 12-myristate 13-acetate; ERGIC, ER–Golgi intermediate compartment; ER, endoplasmic reticulum; VSVG, vesicular stomatitis virus G-protein; CtxB, cholera toxin B subunit; PMA, phorbol 12-myristate 13-acetate; FCCP, carbonylcyanide-p-trifluoromethoxyphenylhydrazone; TMRM, tetramethy
Daidzein regulates secretion, production and gene expression of mucin from airway epithelial cells stimulated by proinflammatory factor and growth factor
Keywords: PMA، phorbol 12-myristate 13-acetate; Airway; Mucin; MUC5AC; DaidzeinEGF, epidermal growth factor; PMA, phorbol 12-myristate 13-acetate; PBS, phosphate-buffered saline; RT-PCR, reverse transcription – polymerase chain reaction; ELISA, enzyme-linked immunosorbent assay
Inhibition of airway MUC5AC mucin production and gene expression induced by epidermal growth factor or phorbol ester by glycyrrhizin and carbenoxolone
Keywords: PMA، phorbol 12-myristate 13-acetate; EGF, epidermal growth factor; PMA, phorbol 12-myristate 13-acetate; PBS, phosphate-buffered saline; RT-PCR, reverse transcription-polymerase chain reaction; ELISA, enzyme-linked immunosorbent assayAirway mucin; MUC5AC gene; Glycyrrhizin; Carbenoxolone
Protein kinase C downregulates IKs by stimulating KCNQ1-KCNE1 potassium channel endocytosis
Keywords: PMA، phorbol 12-myristate 13-acetate; Endocytosis; IKs; KCNE1; KCNQ1; PKC; TraffickingCHO, Chinese hamster ovary; IKs, slow-activating cardiac delayed rectifier K+ current; LQT, long QT; PBS, phosphate-buffered saline; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate
Helicobacter pylori-infected macrophages induce Th17 cell differentiation
Keywords: PMA، phorbol 12-myristate 13-acetate; CCL20, chemokine (CC motif) ligand 20; IFN-γ, interferon-γ; IL, interleukin; MAPKs, mitogen activated protein kinases; PMA, phorbol 12-myristate 13-acetate; RORγt, retinoid-related orphan receptor gamma t; T-bet, T box expressed in T cells; TGF-β1, transf
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets
Keywords: PMA، phorbol 12-myristate 13-acetate; ACR, American College of Rheumatology; CIA, Collagen-induced arthritis; PBMCs, Peripheral blood mononuclear cells; PMA, Phorbol 12-myristate 13-acetate; RA, Rheumatoid arthritis; SD, Standard deviation; TCR, T cell receptor; Tregs, Regulatory T cellsAnti-
Induction of a Th17 cell response by Helicobacter pylori Urease subunit B
Keywords: PMA، phorbol 12-myristate 13-acetate; IFN-γ, interferon-γ; PMA, phorbol 12-myristate 13-acetate; IL, interleukin; TGF-β, transforming growth factor-βHelicobacter pylori; UreB; Th17
The antimicrobial peptide, tilapia hepcidin 2-3, and PMA differentially regulate the protein kinase C isoforms, TNF-α and COX-2, in mouse RAW264.7 macrophages
Keywords: PMA، phorbol 12-myristate 13-acetate; AMP, antimicrobial peptide; COX-2, cycloxygenase-2; PMA, phorbol 12-myristate 13-acetate; TH2-3, tilapia hepcidin 2-3; TNF-α, tumor necrosis factor-α; PKC, protein kinase CAntimicrobial peptide; Tilapia hepcidin 2-3; PMA; PKC; TNF-α; COX-2
Specific activation of human neutrophils by scorpion venom: A flow cytometry assessment
Keywords: PMA، phorbol 12-myristate 13-acetate; FITC, fluorescein isothiocyanate; H2DCFDA-SE, 2′,7′-dichlorodihydrofluorescein diacetate, succinimidyl ester; Nav, voltage-sensitive sodium channel; NOX, NADPH oxidase; PAF, platelet activating factor; PMA, phorbol 12-myristate 13-acetate; PKC, protein ki
Immunomodulatory and therapeutic activity of curcumin
Keywords: PMA، phorbol 12-myristate 13-acetate; Ag, antigen; Ab, antibody; NO, nitric oxide; LPS, lipopolysaccharide; ConA, concanavalin A; AP-1, activator protein 1; NF-κB, nuclear factor-kappaB; NF-AT, nuclear factor of activated T cells; PMA, phorbol 12-myristate 13-acetate; PHA, phytohaemagglutinin
Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions
Keywords: PMA، phorbol 12-myristate 13-acetate; CL, chemiluminescence; HBSS, Hank’s balanced salt solution; LOD, limit of detection; MFI, median fluorescence intensity; OVA, ovalbumin; OVA-DQ, DQ ovalbumin; PAM, primary alveolar macrophages; PI, propidium iodide; PMA, phorbol 12-myristate 13-acetate; P
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line
Keywords: PMA، phorbol 12-myristate 13-acetate; PKC, protein kinase C; DMSO, dimethylsulfoxide; ERK, extracellular signal-regulated kinases; MEK, MAPK/ERK kinase 1; MAPK, mitogen-activated protein kinase; JNK, cJun N-terminal kinases; PMA, phorbol 12-myristate 13-acetate; HAART, highly active antiretro
Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in U937 cells
Keywords: PMA، phorbol 12-myristate 13-acetate; CL, chemiluminescence; FITC, fluorescein isothiocyanate; O2-, superoxide anion; PMA, phorbol 12-myristate 13-acetate; RA, retinoic acid; VD3, vitamin D3Curcumin; Differentiation; Retinoic acid; Superoxide; U937
Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
Keywords: PMA، phorbol 12-myristate 13-acetate; DPI, diphenylene iodonium; EC, endothelial cells; IL-8, interleukin 8; NCM, neutrophil culture medium; NET, neutrophil extracellular trap; PMA, phorbol 12-myristate 13-acetate; PMN, polymorphonuclear neutrophil; SVV, small vessel vasculitis; TNFα, tumor n
mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation
Keywords: PMA، phorbol 12-myristate 13-acetate; S6K1, p70 S6 kinase 1; MAPK, mitogen-activated protein kinase; RSK, p90 ribosomal S6 kinase; mTOR, mammalian target of rapamycin; ERα, estrogen receptor α; PMA, phorbol 12-myristate 13-acetate; PKC, protein kinase Cp70 S6 kinase 1; p90 ribosomal S6 kinase
Glucose-induced translocation of coronin 3 regulates the retrograde transport of the secretory membrane in the pancreatic β-cells
Keywords: PMA، phorbol 12-myristate 13-acetate; GAPs, GTPase-activating proteins; GFP, green fluorescent protein; MOI, multiplicity of infection; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; siRNA, small interfering RNARab27; Coronin; Endocytosis; Insulin granule; Pancreatic β-cell; Sma
Macrophage suppression following phagocytosis of apoptotic neutrophils is mediated by the S100A9 calcium-binding protein
Keywords: PMA، phorbol 12-myristate 13-acetate; Apoptotic neutrophils; Calcium-binding proteins; Inflammation; Macrophage suppression; Resistance to infection; S100A9MDF, macrophage deactivating factor; ROS, reactive oxygen species; LPS, lipopolysaccharide; PMA, phorbol 12-myristate 13-acetate; SSZ, su
Keratinocyte differentiation induced by calcium, phorbol ester or interferon-γ elicits distinct changes in the retinoid signalling pathways
Keywords: PMA، phorbol 12-myristate 13-acetate; CRABPII, cellular RA-binding protein II; ddRA, 3,4-didehydroretinoic acid; DMSO, dimethyl sulfoxide; IFNγ, interferon-γ; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PMA, phorbol 12-myristate 13-acetate; RA, all-trans retinoic acid; RAR
Prosurvival and proapoptotic functions of ERK1/2 activation in murine thymocytes in vitro
Keywords: PMA، phorbol 12-myristate 13-acetate; s/s, serum starvation; PMA, phorbol 12-myristate 13-acetate; IM, ionomycin; SOV, sodium orthovanadate; PI, propidium iodideThymocyte; Apoptosis; Rodent; ERK; MAPK
An oxidative environment promotes growth of Mycobacterium abscessus
Keywords: PMA، phorbol 12-myristate 13-acetate; MnTE-2-PyP, manganese(II) meso-tetrakis-(N-methylpyridinium-2-yl) porphyrin; NAC, N-acetyl-l-cysteine; NTM, nontuberculous mycobacteria; PMA, phorbol 12-myristate 13-acetate; CFU, colony-forming units; SOD, superoxide dismutase; GPx, glutathione peroxidas
Role of protein kinase Cζ in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers
Keywords: PMA، phorbol 12-myristate 13-acetate; HMEC, human dermal microvessel endothelial cells; IEJs, inter-endothelial junctions; TER, transendothelial electrical resistance; MLC, myosin light chain; dn, dominant-negative; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; 4α-PDD, 4α-phorb
Assay conditions can influence the outcome of cytotoxicity tests of nanomaterials: Better assay characterization is needed to compare studies
Keywords: PMA، phorbol 12-myristate 13-acetate; CNT, carbon nanotubes; DMEM, Dulbecco’s modified Eagle medium; HBSS, Hanks’ Balanced Salt Solution; HBSS+, HBSS with Ca2+ and Mg+; HBSS−, HBSS without Ca2+ and Mg+; FCS, foetal calf serum; PMA, phorbol 12-myristate 13-acetate; MTT, methylthiazolyldiphenyl
Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion
Keywords: PMA، phorbol 12-myristate 13-acetate; edema; migration; signalling; tumor; volume regulationAQP, aquaporins; ClC2, chloride channel; KCC1, K+–Cl− cotransporter 1; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate
Effects of hydroquinone and its glucoside derivatives on melanogenesis and antioxidation: Biosafety as skin whitening agents
Keywords: PMA، phorbol 12-myristate 13-acetate; d-Arb, deoxyarbutin; ROS, reactive oxygen species; 8mop, 8-methoxypsoralen; MTT, methyl thiazole tetrazolium; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; PMA, phorbol 12-myristate 13-acetate; D-PBS, Dulbecco's phosphate buffered saline; UVA, ultr
The resetting of the circadian rhythm by Prostaglandin J2 is distinctly phase-dependent
Keywords: PMA، phorbol 12-myristate 13-acetate; PGJ2, prostaglandin J2; Dex, dexamethasone; FK, forskolin; DMSO, dimethyl sulfoxide; PMA, phorbol 12-myristate 13-acetate; SCN, suprachiasmatic nucleus; PRC, phase response curveCircadian rhythm; Prostaglandin J2; Phase shift; Per1; Dark pulse; Clock gene