کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048934 | 1074106 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Members of the homeodomain-interacting protein kinase (HIPK) family are involved in various intracellular regulatory mechanisms. The present study focused on clarifying the functions of HIPK family members in ocular organization during late embryogenesis. HIPK1 and HIPK2 were expressed in the inner retina during late embryogenesis. Hipk1+/−Hipk2−/− mice had a greater frequency of small eyes with a lens deficiency and abnormally laminated and thickened retinas than did wild-type littermates. These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3233–3238
Journal: FEBS Letters - Volume 584, Issue 14, 16 July 2010, Pages 3233–3238
نویسندگان
Toshihiro Inoue, Tetsushi Kagawa, Miyuki Inoue-Mochita, Kyoichi Isono, Naoki Ohtsu, Ikuo Nobuhisa, Mikiko Fukushima, Hidenobu Tanihara, Tetsuya Taga,