کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2048991 1074108 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amyloid β-induced erythrocytic damage and its attenuation by carotenoids
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Amyloid β-induced erythrocytic damage and its attenuation by carotenoids
چکیده انگلیسی

The presence of amyloid β-peptide (Aβ) in human blood has recently been established, and it has been hypothesized that Aβ readily contacts red blood cells (RBC) and oxidatively impairs RBC functions. In this study, we conducted in vitro and in vivo studies, which provide evidence that Aβ induces oxidative injury to RBC by binding to them, causing RBC phospholipid peroxidation and diminishing RBC endogenous carotenoids, especially xanthophylls. This type of damage is likely to injure the vasculature, potentially reducing oxygen delivery to the brain and facilitating Alzheimer’s disease (AD). As a preventive strategy, because the Aβ-induced RBC damage could be attenuated by treatment of RBC with xanthophylls, we suggest that xanthophylls may contribute to the prevention of AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 8, 20 April 2011, Pages 1249–1254
نویسندگان
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