کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049101 1074116 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy
چکیده انگلیسی

The EGF-receptor is frequently mutated in a large variety of tumors. Here we review the most frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase activity, or they represent loss-of-function of suppressive regulatory domains. Interestingly, the constitutive activity of mutant receptors translates to downstream pathways, which are subtly different from those stimulated by the wild-type receptor. Cancer drugs intercepting EGFR signaling have already entered clinical application. Both kinase inhibitors specific to EGFR, and monoclonal antibodies to the receptor are described, along with experimental approaches targeting the HSP90 chaperone. Deeper understanding of signaling pathways downstream to mutant receptors will likely improve the outcome of current EGFR-targeted therapies, as well as help develop new drugs and combinations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 12, 18 June 2010, Pages 2699–2706
نویسندگان
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