کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2049190 | 1074119 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b](/preview/png/2049190.png)
Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP-4-induced osteoblastic differentiation of bone marrow-derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR-210, respectively. A reporter assay demonstrated that the activin A receptor type 1B (AcvR1b) gene was a target for miR-210. Furthermore, inhibition of transforming growth factor-β (TGF-β)/activin signaling in ST2 cells with SB431542 promoted osteoblastic differentiation. We conclude that miR-210 acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-β/activin signaling pathway through inhibition of AcvR1b.
Journal: FEBS Letters - Volume 583, Issue 13, 7 July 2009, Pages 2263–2268